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181 Overproduction of collagen and hyaluronic acid creates a dense ECM that impedes drug diffusion and immune infiltration

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Operating as a high-affinity positive allosteric modulator of Hepatocyte Growth Factor (HGF), Dihexa binds HGF to potentiate c-Met receptor tyrosine kinase signaling

Common GLP-1 agonists include: Semaglutide (Ozempic, Wegovy) Liraglutide (Victoza, Saxenda) Dulaglutide (Trulicity) Tirzepatide (Zepbound) While initially used for diabetes management, studies showed that GLP-1 agonists also contribute significantly to weight loss, leading to their approval for obesity treatment as well

Regen Biomater 11:rbae043